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Subject: US Researcher Links MMR to AutismDate: Wed, 7 Nov 2001 08:33:58 -0800
Dear Members and Friends -
US Researcher Links MMR to Autism, by Alan R. Yurko
A highly respected and well-published scientist at the Utah State University, Vijendra K. Singh has further linked autism to the MMR vaccine. His study published in New Foundation of Biology, Elsevier Science BV 2001: 447-58 Neuropathologies in Autism provides brain autoantibody and virus serology evidence that links autism to MMR and postulates autism as a neuroautoimmune response that occurs at the neuroimmune biological interface.
Singh found that autoantibodies to myelin basic proteins were present in 80% of autistic children but that none were found in the normal children control group and only rarely in all other controls. These autoantibodies attack the basic proteins that constitute myelin, which surrounds the sheaths of nerve fibers. Regarding the virus serology, autistic children had a significantly higher level of measles virus antibodies as compared to controls, which suggests a temporal link of measles virus with autoimmunity in autism.
Furthermore, Singh found a very important serological association between measles antibody level and antiMBP, which showed that the higher the measles antibody titer the greater the chance of autoantibodies to myelin basic protein. The shocking fact is that none of the children had a wild-type measles infection, but they all had the measles mumps rubella (MMR) vaccine.
Singh also offers hope. He notes an open label trial of oral Sphingolin (myelin containing autoantigen) is being assessed. Preliminary results show significant improvement in autistic people, which further support the neuroimmune pathogenesis in autism. -transcribed by Susan Kreider
Vijendra K. Singh, Department of Biology and Biotechnology Center, Utah State University, Logan, Utah, USA 84322-5305