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Do Vaccines contain Antifreeze?
Yes  |   No/Maybe?  |   More antifreeze Coming in Vaccines

References  |   Definitions, Notes and informative links
Propylene Glycol (Polyethylene Glycol)
Our question should be reworded to read, "Do Vaccines contain the active ingredient of antifreeze?"

The most common form of antifreeze contains ethylene glycol and we will discuss that shortly.

A less common form of antifreeze contains propylene glycol. Propylene glycol is sometimes used as a food additive and the CDC says that propylene glycol is '“generally recognized as safe” (GRAS) additive for foods and medications. Propylene glycol rarely causes toxic effects, and then only under very unusual circumstances. ' (1)

One unusual circumstance the CDC notes is a case of propylene glycol poisoning under a condition of high dose absorption. This is not likely applicable to vaccination. The CDC also notes that skin sensitization (allergy) can result. Given that allergies and asthma are elevated in vaccinated children the injection of propylene glycol may be connected. (Writers opinion not the CDC) The CDC does not specify if direct injection of this compound would constitute "very unusual circumstances."

Some vaccines do contain a Propylene Glycol also known as Polyethylene Glycol.

An article on the hazards of Polyethylene Glycol and related compounds in cosmetics is here at

Ethylene Glycol
Several places on the Internet list antifreeze (ethylene glycol) as an ingredient of vaccines. Other sources say "no" there is no antifreeze, meaning no ethylene glycol, in vaccines. The confusion arises due to a similarity of names and the fact that Ethylene Glycol (2) is the name of a class of compounds, one of which, 2-Phenoxyethanol, is sometimes included as an ingredient in vaccines. (3) Two synonyms for 2-Phenoxyethanol are ethylene glycol phenyl ether and ethylene glycol monophenyl ether.

So maybe what we should be asking is the question, "Does ethylene glycol phenyl ether (2-Phenoxyethanol) contain ethylene glycol? While I am not a chemist, I think we have to say that ethylene glycol phenyl ether does contain ethylene glycol as an integral part of its chemical formula. "Ethylene glycol, HOCH2CH2OH, is the simplest member of the glycol family." (4) However, based on an internet search, ethylene glycol phenyl ether is not used in antifreeze and has a different chemical formula than the ethylene glycol used in antifreeze.

So, as far as answering, Yes or No, to the question, "do vaccines contain ethylene glycol", feel free to answer whatever you think best. Either way, you will have lots of company.

A cautious answer is that some vaccines contain 2-Phenoxyethanol a.k.a. ethylene glycol phenyl ether which is somewhat different than the ethylene glycol used in antifreeze.

However, like many other compounds used in vaccines, the safety of this chemical when injected into human bodies is in question. The compound known as 2-Phenoxyethanol or just plain phenoxyethanol is listed by a former FDA Investigator as: "Phenoxyethanol: EDF Suspected - developmental toxicant, reproductive toxicant (aka: Antifreeze). Less hazardous than most chemicals in 3 ranking systems."(5)

More antifreeze in vaccines is on its way
The January 22, 2009 Headline of reads, "Seattle biotech develops vaccine antifreeze."

"Most vaccines must be kept within a fairly precise temperature range to remain effective, and you can't tell if a vaccine has been overheated or frozen just by looking at it.

The U.S. Centers for Disease Control and Prevention estimates that poor refrigeration wastes hundreds of thousands of doses of vaccine every year." (6)

"They report in the current edition of the journal Vaccine on their successful use of common food additives - glycerin, propylene glycol and polyethylene glycol - to protect vaccines from freezing." (7)

While the vaccines are being protected by antifreeze, studies that prove that vaccines are harmful to our children are buried beneath walls of denial.

Definitions, Notes and informative links


Ethylene Glycols
An ethylene compound with two hydroxy groups (-OH) located on adjacent carbons. They are viscous and colorless liquids. Some are used as anesthetics or hypnotics. However, the class is best known for their use as a coolant or antifreeze.

The category of Ethylene Glycols includes:
methyl cellosolve (Solvents,. Pharma Action Immunosuppressive Agents ; Teratogens),
n-butoxyethanol (Ethers Solvents), 2-ethoxyethanol (Solvents),
phenoxyethanol, (Anesthetics ; Anti-Infective Agents),


Compiled By Arthur M. Evangelista, a former FDA Investigator
Posted: 28 May 2004
Source: 1997 Physicians' Desk Reference

Phenol : EDF Suspected - cardiovascular or blood toxicant aka Carbolic Acid - developmental toxicant, gastrointestinal or liver toxicant kidney toxicant, neurotoxicant respiratory toxicant, skin or sense organ toxicant.
More hazardous than most chemicals in 3 out of 10 ranking systems.
On at least 8 federal regulatory lists.

Phenoxyethanol: EDF Suspected - developmental toxicant, reproductive toxicant (aka: Antifreeze).
Less hazardous than most chemicals in 3 ranking systems.


(7) See number 6 above.

Definitions, Notes and Informative Links
toxic ethylene glycol, and the food additive propylene glycol, both of which make good anti-freeze components,

Dangers of Propylene Glycol
Because What You Need Is an Intramuscular Injection of Propylene Glycol!
So we have the CDC saying that injections of propylene glycol-containing medications are risky, particularly for infants (that's "neonate," in code). Then you have some researchers telling us how great it is to put propylene glycol into our vaccines so they don't freeze. Hmm.!80EE15D075B65A13!927.entry

Phenoxyethanol is an organic chemical compound, a glycol ether often used in dermatological products such as skin creams and sunscreen. It is a colorless oily liquid. It is a bactericide (usually used in conjunction with quaternary ammonium compounds), often used in place of sodium azide in biological buffers as 2-phenoxyethanol is less toxic and non-reactive with copper and lead. It is also used as a fixative for perfumes, an insect repellent, a topical antiseptic, a solvent for cellulose acetate, some dyes, inks, and resins, in preservatives, pharmaceuticals, and in organic synthesis. It is moderately soluble in water. It is used as an anesthetic in the aquaculture of some fish[1][2].

It is also listed as an ingredient for many United States vaccines by the Center for Disease Control. [3]
Safety data for 2-phenoxyethanol
Two synonyms:
ethylene glycol phenyl ether and ethylene glycol monophenyl ether
Molecular formula: C8H10O2
One of the synonyms for Ethylene glycol is: Monoethylene glycol

Anti-Infective Agents, Local
Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.

Agents that are capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.
Interview of PAUL OFFIT, M.D.
Chief of infectious diseases at Children's Hospital of Philadelphia and co-inventor of and holder of the patent for the rotavirus vaccine.

"Vaccines don't contain antifreeze. One particular vaccine contains one component of antifreeze, propylene glycol. Propylene glycol is in many products we use, including salad dressing."

Formulation developed to stop vaccine freeze damage
By Nick Taylor, 26-Jan-2009

Related topics: Materials & Formulation, Ingredients, excipients and raw materials

Health charity PATH has developed a formulation to stop vaccines suffering from freeze damage, which it believes will help ensure products are fully potent when they reach their destination.

The work, details of which have been published in Vaccine volume 27, issue 1, was performed in conjunction with researchers at the University of Colorado.

By adding a small amount of freeze-protection stabilisers, such as glycerin, polyethylene glycol 300, or propylene glycol, to vaccines containing aluminium adjuvants damage from freezing was prevented.

The freeze-protection stabilisers have previously safely been used in human medications and PATH believes they can also be applied to vaccines for hepatitis B, diphtheria, tetanus toxoid and pertussis.

PATH has performed laboratory and preclinical studies with the formulations and has now placed the technology in the public domain so that vaccine manufacturers can use it.

There are currently two vaccine producers working to incorporate the technology into their formulations and PATH hopes others will also adopt the process.

By utilising the technology PATH believes that vaccine manufacturers can ensure that vaccines are fully potent when administered. In addition the technology could help reduce waste as vaccines are thrown away when health workers suspect they have been exposed to freezing.

PATH identified damage from freezing as a problem after reviewing 25 published and 10 unpublished articles on cold-chain transportation and storage of vaccines in developed and developing countries.

These studies found that vaccines are frequently subjected to temperatures below freezing despite the World Health Organization recommending all vaccines, except oral polio, are stored at 2°C to 8°C.